BDBM50524286 CHEMBL4447797

SMILES COc1cc2nccc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1OC

InChI Key InChIKey=ZVEOYXBOCQWWQG-UHFFFAOYSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50524286   

TargetEpidermal growth factor receptor(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50524286(CHEMBL4447797)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50524286(CHEMBL4447797)
Affinity DataKd:  32nMAssay Description:Binding affinity to wild-type human partial length EGFR (R669 to V1011 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50524286(CHEMBL4447797)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to wild-type human partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed