BDBM50524280 CHEMBL4446630

SMILES COc1cc(Nc2ncnc3ccc(cc23)C(F)(F)F)cc(OC)c1OC

InChI Key InChIKey=OGYXEJMRZBYWMY-UHFFFAOYSA-N

Data  2 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50524280   

TargetEpidermal growth factor receptor(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50524280(CHEMBL4446630)
Affinity DataKd:  6.10E+3nMAssay Description:Binding affinity to wild-type human partial length EGFR (R669 to V1011 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50524280(CHEMBL4446630)
Affinity DataKd:  190nMAssay Description:Binding affinity to wild-type human partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50524280(CHEMBL4446630)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50524280(CHEMBL4446630)
Affinity DataKd:  130nMAssay Description:Binding affinity to human wild type partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by KinomeScan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50524280(CHEMBL4446630)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of GAK (unknown origin) by in-cell pulse based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed