BDBM50523494 CHEMBL4574678

SMILES OC[C@H]1CCCN1Cc1ccc(COc2cccc(OCc3ccccc3)c2)cc1

InChI Key InChIKey=SPXSEZMVRJLHQG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50523494   

TargetSphingosine kinase 2(Human)
Heriot-Watt University

Curated by ChEMBL
LigandPNGBDBM50523494(CHEMBL4574678)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged SK2 expressed in baculovirus infected Sf9 insect cells using Sph as substrate measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Heriot-Watt University

Curated by ChEMBL
LigandPNGBDBM50523494(CHEMBL4574678)
Affinity DataIC50: 14nMAssay Description:Inhibition of GFP-tagged SK1 (unknown origin) expressed in HEK293 cells using Sph as substrate measured after 30 mins in presence of [gamma32P]ATP by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Heriot-Watt University

Curated by ChEMBL
LigandPNGBDBM50523494(CHEMBL4574678)
Affinity DataIC50: 446nMAssay Description:Inhibition of SphK1 (unknown origin) using D-Sph as substrate incubated for 40 mins by ADP-Glo Plus luminescence kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSphingosine kinase 2(Human)
Heriot-Watt University

Curated by ChEMBL
LigandPNGBDBM50523494(CHEMBL4574678)
Affinity DataIC50: 11nMAssay Description:Inhibition of SphK2 (unknown origin) using NBD-Sph as substrate by fluorescent plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed