BDBM50523172 CHEMBL4460355

SMILES CNC(=O)c1c(oc2cc(c(cc12)C1CC1)-n1nnnc1-c1ccc(B(O)O)c(Cl)c1)-c1ccc(F)cc1

InChI Key InChIKey=QDESALDWVFNBLH-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50523172   

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50523172(CHEMBL4460355)
Affinity DataEC50:  3.80nMAssay Description:Inhibition of HCV genotype 1a wild-type NS5B RNA dependent RNA polymerase transfected in human HuH7 Lunet replicon cells assessed as reduction in vir...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50523172(CHEMBL4460355)
Affinity DataEC50:  5nMAssay Description:Inhibition of HCV genotype 1b wild-type NS5B RNA dependent RNA polymerase infected in human HuH7 Lunet replicon cells assessed as reduction in viral ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50523172(CHEMBL4460355)
Affinity DataEC50:  660nMAssay Description:Inhibition of HCV genotype 1a NS5B RNA dependent RNA polymerase C316Y mutant transfected in human HuH7 Lunet replicon cells assessed as reduction in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50523172(CHEMBL4460355)
Affinity DataEC50:  40nMAssay Description:Inhibition of HCV genotype 1b NS5B RNA dependent RNA polymerase C316N mutant infected in human HuH7 Lunet replicon cells assessed as reduction in vir...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed