BDBM50522505 CHEMBL4469678

SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(-c2c(Cl)cccc2Cl)c3=O)C2COC2)cc1

InChI Key InChIKey=SMXRRJDAWALKLK-UHFFFAOYSA-N

Data  1 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50522505   

TargetWee1-like protein kinase(Human)
Global Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50522505(CHEMBL4469678)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to wild type N-terminal GST-tagged human WEE1 catalytic domain (215 to 646 residues) expressed in baculovirus expression system meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetWee1-like protein kinase(Human)
Global Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50522505(CHEMBL4469678)
Affinity DataEC50:  324nMAssay Description:Inhibition of WEE1 in human NCI-H1299 cells assessed as reduction in Cdc2 phosphorylation at Tyr15 residue measured after 6 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed