BDBM50521568 CHEMBL4444408

SMILES FC(F)(F)[C@H]1CCN([C@H]2CCOc3cc(ccc23)S(=O)(=O)Nc2ncns2)[C@H](C1)c1ccccc1

InChI Key InChIKey=BLBWZXOCNRJPSB-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50521568   

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50521568(CHEMBL4444408)
Affinity DataIC50: 0.570nMAssay Description:Inhibition of full length human Nav1.7 expressed in HEK293 cells assessed as reduction of current amplitude at -60 mV holding potential measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50521568(CHEMBL4444408)
Affinity DataKi:  0.970nMAssay Description:Displacement of [3H]GX-545 from full length human Nav1.7 VSD4 domain expressed in HEK cell membranes measured after 20 hrs by liquid scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed