BDBM50521253 CHEMBL4566835

SMILES [H][C@@]12CN(CCN1c1nc(NCCN(C)C)nc3cc(c(Cl)c(OC2)c13)-c1c(C)ccc2[nH]ncc12)C(=O)C=C

InChI Key InChIKey=BTSLADGESTVJLG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50521253   

TargetGTPase KRas(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50521253(CHEMBL4566835)
Affinity DataIC50: 18nMAssay Description:Inhibition of GDP loaded biotin-labeled KRAS G12C mutant (unknown origin) assessed as reduction in guanine nucleotide exchange preincubated for 4 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed