BDBM50521237 CHEMBL4468090

SMILES NS(=O)(=O)NCc1nnc(o1)C(c1nc2ccc(cc2s1)-c1ccccc1)S(=O)(=O)Cc1ccccc1

InChI Key InChIKey=XLWWLJLSGXYJJY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50521237   

TargetHepatic triacylglycerol lipase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50521237(CHEMBL4468090)
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant human HL expressed in COS7 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetEndothelial lipase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50521237(CHEMBL4468090)
Affinity DataIC50: 10nMAssay Description:Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetEndothelial lipase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50521237(CHEMBL4468090)
Affinity DataIC50: 76nMAssay Description:Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetEndothelial lipase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50521237(CHEMBL4468090)
Affinity DataIC50: 77nMAssay Description:Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed