BDBM50521227 CHEMBL4473964

SMILES COC(=O)Nc1ccc(cc1)-c1ccc2nc(sc2c1)C(c1nnc(CNS(N)(=O)=O)o1)S(=O)(=O)Cc1ccccc1

InChI Key InChIKey=WHRXSLZLOPSMQN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50521227   

TargetEndothelial lipase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50521227(CHEMBL4473964)
Affinity DataIC50: 21nMAssay Description:Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetEndothelial lipase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50521227(CHEMBL4473964)
Affinity DataIC50: 240nMAssay Description:Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHepatic triacylglycerol lipase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50521227(CHEMBL4473964)
Affinity DataIC50: 90nMAssay Description:Inhibition of recombinant human HL expressed in COS7 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetEndothelial lipase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50521227(CHEMBL4473964)
Affinity DataIC50: 300nMAssay Description:Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed