BDBM50521224 CHEMBL4577903

SMILES CN(C)C(=O)c1ccc(cc1Cl)-c1ccc2nc(sc2c1)C(c1nnc(CNS(N)(=O)=O)o1)S(=O)(=O)Cc1ccccc1

InChI Key InChIKey=JJHPWLJWLANJOG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50521224   

TargetEndothelial lipase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50521224(CHEMBL4577903)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHepatic triacylglycerol lipase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50521224(CHEMBL4577903)
Affinity DataIC50: 391nMAssay Description:Inhibition of recombinant human HL expressed in COS7 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetEndothelial lipase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50521224(CHEMBL4577903)
Affinity DataIC50: 10nMAssay Description:Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetEndothelial lipase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50521224(CHEMBL4577903)
Affinity DataIC50: 1.19E+3nMAssay Description:Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed