BDBM50521186 CHEMBL4547101::US11260049, Ex. 45

SMILES OC[C@]1(O)CN(C[C@@H]1S(=O)(=O)c1ccc(cc1)C#N)S(=O)(=O)c1ccc(cc1Cl)C#N

InChI Key InChIKey=OUYMKZPBVOUUOB-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50521186   

TargetTransient receptor potential cation channel subfamily V member 4(Human)
TBA

Curated by ChEMBL

LigandBDBM50521186(CHEMBL4547101 | US11260049, Ex. 45)Copy SMILESCopy InChI

Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at human TRPV4 expressed in BHK/AC9 cells assessed as inhibition of GSK634775-induced calcium immobilization pre-incubated for 10...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
Copy Entry DOIPubMed
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TargetTransient receptor potential cation channel subfamily V member 4(Human)
TBA

Curated by ChEMBL

LigandBDBM50521186(CHEMBL4547101 | US11260049, Ex. 45)Copy SMILESCopy InChI

Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/24/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL