BDBM50520945 CHEMBL4584571

SMILES Cn1cccc1-c1ccc(-c2ccc(-c3ccc(-c4ccccc4)n3C)n2C)n1C

InChI Key InChIKey=QRXWBYLQXGFCRY-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50520945   

TargetProprotein convertase subtilisin/kexin type 9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50520945(CHEMBL4584571)
Affinity DataEC50:  6.04E+3nMAssay Description:Inhibition of PCSK9 in human HepG2 cells assessed as increase in LDL uptake after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50520945(CHEMBL4584571)
Affinity DataIC50: 1.12E+4nMAssay Description:Inhibition of wild type His-tagged PCSK9 (unknown origin) binding to recombinant LDLR-AB domain (unknown origin) after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed