BDBM50520590 CHEMBL4533742

SMILES CCC(=O)Nc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC)cc1N(C)CCN(C)C

InChI Key InChIKey=HBTAKNXWIBLHGT-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50520590   

TargetEpidermal growth factor receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50520590(CHEMBL4533742)
Affinity DataEC50:  666nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50520590(CHEMBL4533742)
Affinity DataEC50:  972nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed