BDBM50520156 CHEMBL4577511::US10894784, Example 16.06.02.B
SMILES C[C@H](N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2nc(C)no2)c1
InChI Key InChIKey=SYMILEXMAHCATG-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50520156
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon/Serine/threonine-protein kinase TBK1(Human)
Bayer
Curated by ChEMBL
Bayer
Curated by ChEMBL
Affinity DataIC50: 3.02E+3nMAssay Description:Inhibition of IKKepsilon/TBK1 in human MDB-MB-231 cells transduced with lentiviral vector expressing human IRF3 assessed as decrease in poly(I:C)-sti...More data for this Ligand-Target Pair
Affinity DataIC50: 106nMAssay Description:Inhibition of recombinant full length human N-terminal His-tagged TBK1 using biotin-labelled Ahx-GDEDFSSFAEPG peptide as substrate preincubated with ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.49E+3nMAssay Description:Inhibition of recombinant full length human N-terminal His-tagged TBK1 using biotin-labelled Ahx-GDEDFSSFAEPG peptide as substrate preincubated with ...More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant full length human C-terminal GST-tagged IKKepsilon expressed in baculovirus expression system using biotin-labelled Ahx-GDE...More data for this Ligand-Target Pair
Affinity DataIC50: 17.2nMAssay Description:Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...More data for this Ligand-Target Pair