BDBM50520154 CHEMBL4466150::US10894784, Example 17.02

SMILES FC(F)(F)CC(=O)N1CCN(Cc2ccnc(Nc3nc4ccc(cc4[nH]3)-c3nc(no3)C3CC3)c2)CC1

InChI Key InChIKey=NLHGPDUHURNAHF-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50520154   

TargetSerine/threonine-protein kinase TBK1(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50520154(CHEMBL4466150 | US10894784, Example 17.02)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant full length human N-terminal His-tagged TBK1 using biotin-labelled Ahx-GDEDFSSFAEPG peptide as substrate preincubated with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50520154(CHEMBL4466150 | US10894784, Example 17.02)
Affinity DataIC50: 58nMAssay Description:Inhibition of recombinant full length human N-terminal His-tagged TBK1 using biotin-labelled Ahx-GDEDFSSFAEPG peptide as substrate preincubated with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50520154(CHEMBL4466150 | US10894784, Example 17.02)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of IKKepsilon/TBK1 in human MDB-MB-231 cells transduced with lentiviral vector expressing human IRF3 assessed as decrease in poly(I:C)-sti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50520154(CHEMBL4466150 | US10894784, Example 17.02)
Affinity DataIC50: 41nMAssay Description:Inhibition of recombinant full length human C-terminal GST-tagged IKKepsilon expressed in baculovirus expression system using biotin-labelled Ahx-GDE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50520154(CHEMBL4466150 | US10894784, Example 17.02)
Affinity DataIC50: 69nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged FLT3 (564 to end residues) expressed in sf21 cells using biotin labelled Ahx-GGEEEEYFELVKKKK pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50520154(CHEMBL4466150 | US10894784, Example 17.02)
Affinity DataIC50: 64.9nMAssay Description:Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent