BDBM50520147 CHEMBL4436416::US10894784, Example 37.01

SMILES Cn1cc(cn1)-c1ccc2nc(Nc3cc(CN4CCN(CC4)C(=O)CC(F)(F)F)ccn3)[nH]c2c1

InChI Key InChIKey=RDFHITQJRDVSMP-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50520147   

LigandPNGBDBM50520147(CHEMBL4436416 | US10894784, Example 37.01)
Affinity DataIC50: 197nMAssay Description:Inhibition of recombinant full length human C-terminal GST-tagged IKKepsilon expressed in baculovirus expression system using biotin-labelled Ahx-GDE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50520147(CHEMBL4436416 | US10894784, Example 37.01)
Affinity DataIC50: 1.96E+3nMAssay Description:Inhibition of IKKepsilon/TBK1 in human MDB-MB-231 cells transduced with lentiviral vector expressing human IRF3 assessed as decrease in poly(I:C)-sti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50520147(CHEMBL4436416 | US10894784, Example 37.01)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of recombinant full length human N-terminal His-tagged TBK1 using biotin-labelled Ahx-GDEDFSSFAEPG peptide as substrate preincubated with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50520147(CHEMBL4436416 | US10894784, Example 37.01)
Affinity DataIC50: 240nMAssay Description:Inhibition of recombinant full length human His-tagged CDK9/CyclinT1 expressed in baculovirus expression system using biotin-labelled Ttds-YISPLKSPYK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50520147(CHEMBL4436416 | US10894784, Example 37.01)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged FLT3 (564 to end residues) expressed in sf21 cells using biotin labelled Ahx-GGEEEEYFELVKKKK pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50520147(CHEMBL4436416 | US10894784, Example 37.01)
Affinity DataIC50: 1.12E+4nMAssay Description:Inhibition of recombinant full length human His6-tagged RSK4 expressed in baculovirus infected sf21 cells using biotin labelled Ahx-KKLNRTLSFAEPG pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50520147(CHEMBL4436416 | US10894784, Example 37.01)
Affinity DataIC50: 55nMAssay Description:Inhibition of recombinant full length human N-terminal His-tagged TBK1 using biotin-labelled Ahx-GDEDFSSFAEPG peptide as substrate preincubated with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50520147(CHEMBL4436416 | US10894784, Example 37.01)
Affinity DataIC50: 55.3nMAssay Description:Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
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