BDBM50520043 CHEMBL4549595

SMILES Fc1ccc(Cc2n[nH]c(=O)c3ccccc23)cc1C(=O)N1CCN(CC1)c1nc(nc(n1)-c1ccc2cn[nH]c2c1)N1CCOCC1

InChI Key InChIKey=FMWMCQQWSGHKLT-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50520043   

TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL

LigandBDBM50520043(CHEMBL4549595)Copy SMILESCopy InChI

Affinity DataIC50: 0.676nMAssay Description:Inhibition of recombinant human PARP1 using histone as substrate after 1 hr in presence of biotinylated NAD+ by ELISAMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
TBA

Curated by ChEMBL

LigandBDBM50520043(CHEMBL4549595)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 1 hr by ADP-glo plus luminescence assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL