BDBM50520037 CHEMBL4470724

SMILES Nc1cc(c(cn1)-c1nc2CN(CCc2c(n1)N1CCOCC1)C(=O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)C(F)(F)F

InChI Key InChIKey=LIQDGVXNWJAUNO-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50520037   

TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50520037(CHEMBL4470724)
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human PARP1 using histone as substrate after 1 hr in presence of biotinylated NAD+ by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50520037(CHEMBL4470724)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of recombinant human PARP2 using histone as substrate after 1 hr in presence of biotinylated NAD+ by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50520037(CHEMBL4470724)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 1 hr by ADP-glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50520037(CHEMBL4470724)
Affinity DataIC50: 288nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate measured after 1 hr by ADP-glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50520037(CHEMBL4470724)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate measured after 2 hrs by ADP-glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50520037(CHEMBL4470724)
Affinity DataIC50: 832nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate measured after 1 hr by ADP-glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50520037(CHEMBL4470724)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of PARP1 (unknown origin) incubated for 1 hr by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM50520037(CHEMBL4470724)
Affinity DataIC50: 194nMAssay Description:Inhibition of PI3K-alpha (unknown origin) incubated for 40 mins in presence of ATP by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed