BDBM50519735 CHEMBL4573309

SMILES CCOC(=O)C1=C(C)NC(C)=C(C1c1ccc(OCCCCCN2CCCCC2)cc1)C(=O)OCC

InChI Key InChIKey=LEFLUEYSKFGASD-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50519735   

TargetCholinesterase(Human)
UBFC

Curated by ChEMBL
LigandPNGBDBM50519735(CHEMBL4573309)
Affinity DataIC50: 7.83E+3nMAssay Description:Inhibition of BuChE in human plasma using butyrylthiocholine iodide substrate by Ellman's protocol based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519735(CHEMBL4573309)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of voltage-dependent L-type calcium channel in 70 mM K+-induced human SH-SY5Y cells assessed as blocking of depolarization-induced Ca2+ up...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
UBFC

Curated by ChEMBL
LigandPNGBDBM50519735(CHEMBL4573309)
Affinity DataIC50: 1.40E+3nMAssay Description:Antagonist activity at human H4 receptor expressed in CHO-K1 cells co-expressing G protein alpha16 assessed as inhibition of histamine-induced calciu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
UBFC

Curated by ChEMBL
LigandPNGBDBM50519735(CHEMBL4573309)
Affinity DataKi:  565nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human H3 receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed