BDBM50519641 CHEMBL4439426

SMILES Oc1ccc(cc1)-c1cc2cccnc2[nH]1

InChI Key InChIKey=XZQLYCMLGSOHOX-UHFFFAOYSA-N

Data  3 IC50  3 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50519641   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519641(CHEMBL4439426)
Affinity DataKd:  218nMAssay Description:Binding affinity to human RIPK1 by kinome scan based methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519641(CHEMBL4439426)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of human full length GST-tagged RIPK1 expressed in baculovirus in Sf9 insect cells incubated for 10 mins in presence of [gamma32-ATP] by S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519641(CHEMBL4439426)
Affinity DataEC50:  1.10E+3nMAssay Description:Inhibition of RIPK1 in human FADD-deficient Jurkat I 2.1 cells assessed as protection against TNFalpha-induced necroptosis measured after 24 hrs by M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519641(CHEMBL4439426)
Affinity DataKd:  218nMAssay Description:Binding affinity to human full length GST-tagged RIPK1 expressed in baculovirus infected Sf9 insect cells assessed as dissociation constant by compet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519641(CHEMBL4439426)
Affinity DataIC50: 2.07E+3nMAssay Description:Inhibition of RIPK1 (unknown origin) using MBP substrate incubated for 2 hrs by ADP-Glo kinase function assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519641(CHEMBL4439426)
Affinity DataIC50: 1.03E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50519641(CHEMBL4439426)
Affinity DataKd:  218nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed