BDBM50519631 CHEMBL4460261

SMILES COc1cc(N2CC[S+]([O-])CC2)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cn(C)c2ccccc12

InChI Key InChIKey=PJRDATNRTJXMNR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50519631   

TargetEpidermal growth factor receptor(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50519631(CHEMBL4460261)
Affinity DataIC50: 75nMAssay Description:Inhibition of recombinant human GST-tagged EGFR T790M/L858R mutant expressed in baculovirus expression system using Tyr 04 as substrate incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50519631(CHEMBL4460261)
Affinity DataIC50: 65nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R mutant expressed in baculovirus expression system using Tyr 04 as substrate incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50519631(CHEMBL4460261)
Affinity DataIC50: 421nMAssay Description:Inhibition of recombinant human GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus expression system using Tyr 04 as substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed