BDBM50519522 CHEMBL4578980

SMILES CNC(=O)c1cnc(Nc2cc(C)c(F)cn2)cc1Nc1cccc(C(=O)NCCN2CCOCC2)c1OC

InChI Key InChIKey=XABXBAWXKDATQI-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50519522   

TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1(Human)
TBA

Curated by ChEMBL

LigandBDBM50519522(CHEMBL4578980)Copy SMILESCopy InChI

Affinity DataIC50: 51nMAssay Description:Inhibition of JAK1/TYK2 in human Kit225 T cells assessed as inhibition of STAT phosphorylation by luciferase reporter assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
Copy Entry DOIPubMed
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TargetNon-receptor tyrosine-protein kinase TYK2(Human)
TBA

Curated by ChEMBL

LigandBDBM50519522(CHEMBL4578980)Copy SMILESCopy InChI

Affinity DataIC50: 160nMAssay Description:Inhibition of TYK2 in human whole blood assessed as decrease in IFNalpha-induced STAT5 phosphorylation preincubated for 1 hr followed by stimulation ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL