BDBM50519473 CHEMBL4546097

SMILES CN1c2c(n(c(n2)Oc3cccc(c3)Cl)Cc4ccc(cc4)Cl)C(=O)N(C1=O)CCCO

InChI Key InChIKey=VYJPVPHNGWEIBT-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50519473   

TargetShort transient receptor potential channel 5(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50519473BDBM50519473(CHEMBL4546097)
Affinity DataIC50: 0.520nMAssay Description:Inhibition of human TRPC5 expressed in human T-REx-293 cells assessed as reduction in lanthanum-activated TRPC5-mediated currents by whole-cell patch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetShort transient receptor potential channel 5(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50519473BDBM50519473(CHEMBL4546097)
Affinity DataIC50: 9.30nMAssay Description:Inhibition of human TRPC5 expressed in human T-REx-293 cells assessed as reduction in calcium influx by Fluo-4AM dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetShort transient receptor potential channel 5(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50519473BDBM50519473(CHEMBL4546097)
Affinity DataIC50: 9.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetShort transient receptor potential channel 5(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50519473BDBM50519473(CHEMBL4546097)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetShort transient receptor potential channel 4(Mouse)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50519473BDBM50519473(CHEMBL4546097)
Affinity DataIC50: 17nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetShort transient receptor potential channel 4(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50519473BDBM50519473(CHEMBL4546097)
Affinity DataIC50: 46nMAssay Description:Inhibition of human TRPC4 expressed in human T-REx-293 cells coexpressing M1 receptor assessed as reduction in calcium influx by Fluo-4AM dye based a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetShort transient receptor potential channel 4(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50519473BDBM50519473(CHEMBL4546097)
Affinity DataIC50: 46nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetShort transient receptor potential channel 7(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50519473BDBM50519473(CHEMBL4546097)
Affinity DataIC50: 3.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetShort transient receptor potential channel 3(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50519473BDBM50519473(CHEMBL4546097)
Affinity DataIC50: 3.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetShort transient receptor potential channel 6(Mouse)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50519473BDBM50519473(CHEMBL4546097)
Affinity DataIC50: 3.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed