BDBM50518521 CHEMBL4564586

SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CC3)n([C@H]3CCCNC3)c2n1

InChI Key InChIKey=MPFTYTXJRHGYBP-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50518521   

TargetSerine/threonine-protein kinase pim-1(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518521(CHEMBL4564586)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
LigandPNGBDBM50518521(CHEMBL4564586)
Affinity DataEC50:  28nMAssay Description:Inhibition of PIM in human KG1 cells assessed as reduction in pS6 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518521(CHEMBL4564586)
Affinity DataIC50: 9nMAssay Description:Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed