BDBM50518520 CHEMBL4593810

SMILES CC(O)C#Cc1c(Cl)c2c(Cl)cc(nc2n1[C@H]1CCCNC1)C(N)=O

InChI Key InChIKey=VHIOBYUNOHKXFT-UHFFFAOYSA-N

Data  1 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50518520   

TargetSerine/threonine-protein kinase pim-1(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518520(CHEMBL4593810)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518520(CHEMBL4593810)
Affinity DataIC50: 9.30nMAssay Description:Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
LigandPNGBDBM50518520(CHEMBL4593810)
Affinity DataEC50:  13nMAssay Description:Inhibition of PIM in human KG1 cells assessed as reduction in pS6 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518520(CHEMBL4593810)
Affinity DataKi:  0.700nMAssay Description:Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed