BDBM50518517 CHEMBL4540910

SMILES COCCC#Cc1c(Cl)c2c(Cl)cc(nc2n1[C@H]1CCCNC1)C(N)=O

InChI Key InChIKey=NEBCCMOWOJKFFS-UHFFFAOYSA-N

Data  1 KI  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50518517   

LigandPNGBDBM50518517(CHEMBL4540910)
Affinity DataIC50: 3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518517(CHEMBL4540910)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518517(CHEMBL4540910)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
LigandPNGBDBM50518517(CHEMBL4540910)
Affinity DataEC50:  27nMAssay Description:Inhibition of PIM in human KG1 cells assessed as reduction in pS6 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518517(CHEMBL4540910)
Affinity DataKi:  0.400nMAssay Description:Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed