BDBM50518449 CHEMBL4435950

SMILES CC(C)(C)CC(=O)NC(C(=O)NO)c1ccc(cc1)-c1cc(F)c(F)c(F)c1

InChI Key InChIKey=NRAVUPOEFDEIOQ-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50518449   

Target72 kDa type IV collagenase(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM50518449(CHEMBL4435950)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of MMP2 (unknown origin) preincubated for 1 hr followed by (QF)-24 substrate addition measured at 1 min time interval for 1 hr by fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM50518449(CHEMBL4435950)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of MMP9 (unknown origin) preincubated for 1 hr followed by (QF)-24 substrate addition measured at 1 min time interval for 1 hr by fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetAminopeptidase N(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM50518449(CHEMBL4435950)
Affinity DataKi:  300nMAssay Description:Inhibition of human APN expressed in HEK293 cells preincubated for 20 mins followed by L-leucine-7-amido-4-methylcoumarin addition by fluorescence as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed