BDBM50517797 CHEMBL4581474

SMILES COc1ncc(cc1C)N1CCc2ncnc(-c3ccnc(N[C@H]4CC[C@H](O)CC4)c3)c2C1

InChI Key InChIKey=RXKIAMVXRIBVOB-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50517797   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Astellas Pharma

Curated by ChEMBL

LigandBDBM50517797(CHEMBL4581474)Copy SMILESCopy InChI

Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of human PI3Kalpha using phosphatidyl inositol as substrate after 3 hrs by Kinase-Glo Plus reagent-based luminescence assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/22/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Astellas Pharma

Curated by ChEMBL

LigandBDBM50517797(CHEMBL4581474)Copy SMILESCopy InChI

Affinity DataIC50: 27nMAssay Description:Inhibition of recombinant human PI3Kdelta using PIP2 as substrate after 35 to 40 mins by HTRF assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/22/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL