BDBM50517669 CHEMBL4594002

SMILES O[C@H]1CC[C@H](CNC2C3CC4CC2CC(CNc2nc(NCc5ccccc5C(F)(F)F)ncc2C#N)(C4)C3)CC1

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50517669   

TargetProtein kinase C theta type(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50517669(CHEMBL4594002)
Affinity DataIC50: 0.570nMAssay Description:Inhibition of recombinant human full length PKCtheta using biotin-labelled STK substrate-1 as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50517669(CHEMBL4594002)
Affinity DataIC50: 17nMAssay Description:Inhibition of PKCtheta in human Jurkat cells assessed as reduction in IL2 production after 14 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed