BDBM50517596 CHEMBL4450505

SMILES CC(C)C[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cnc(C)s1)C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O

InChI Key InChIKey=DYMSMUGVJHOWOY-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50517596   

TargetProteasome subunit beta type-2(Human)
Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517596(CHEMBL4450505)
Affinity DataIC50: 18nMAssay Description:Inhibition of 20S constitutive proteasome beta 2 trypsin-like activity (unknown origin) by cell based ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517596(CHEMBL4450505)
Affinity DataIC50: 540nMAssay Description:Inhibition of 20S immunoproteasome beta 2 (unknown origin) by cell based ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-2(Human)
Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517596(CHEMBL4450505)
Affinity DataIC50: 65nMAssay Description:Inhibition of 20S constitutive proteasome beta 2 trypsin-like activity in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517596(CHEMBL4450505)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 20S constitutive proteasome beta 5 chymotrypsin-like activity in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517596(CHEMBL4450505)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 20S immunoproteasome beta 2 in human RPMI8226 cell lysates after 1 hr by coomassie brilliant blue staining-based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517596(CHEMBL4450505)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 20S constitutive proteasome beta 5 chymotrypsin-like activity in human RPMI8226 cell lysates after 1 hr by coomassie brilliant blue sta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517596(CHEMBL4450505)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 20S immunoproteasome beta 5 in human RPMI8226 cell lysates after 1 hr by coomassie brilliant blue staining-based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-9(Human)
Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517596(CHEMBL4450505)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 20S immunoproteasome beta 1 in human RPMI8226 cell lysates after 1 hr by coomassie brilliant blue staining-based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517596(CHEMBL4450505)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 20S immunoproteasome beta 5 in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-9(Human)
Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517596(CHEMBL4450505)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 20S immunoproteasome beta 1 in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517596(CHEMBL4450505)
Affinity DataIC50: 420nMAssay Description:Inhibition of 20S immunoproteasome beta 2 in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517596(CHEMBL4450505)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 20S constitutive proteasome beta 1 caspase-like activity in human RPMI8226 cell lysates after 1 hr by coomassie brilliant blue staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517596(CHEMBL4450505)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 20S constitutive proteasome beta 1 caspase-like activity in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-2(Human)
Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL
LigandPNGBDBM50517596(CHEMBL4450505)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 20S constitutive proteasome beta 2 trypsin-like activity in human RPMI8226 cell lysates after 1 hr by coomassie brilliant blue staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed