BDBM50516758 CHEMBL4444471::US11542283, Compound V-9A

SMILES CSC[C@H](NC(=O)c1cc(Cl)ccc1Cl)C(=O)N[C@@H](CC(C)C)B1OCCNCCO1

InChI Key InChIKey=GNNMNVFGCQSIQV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50516758   

TargetProteasome subunit beta type-5(Human)
S£O Paulo State University

Curated by ChEMBL
LigandPNGBDBM50516758(CHEMBL4444471 | US11542283, Compound V-9A)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human chymotrypsin-like activity of 20S proteasome (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM50516758(CHEMBL4444471 | US11542283, Compound V-9A)
Affinity DataIC50: 5.69nMAssay Description:The proteasome used in the present invention is human erythrocyte 20S proteasome, and the enzyme, fluorescent substrate and test buffer are all purch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent