BDBM50516532 CHEMBL4560679

SMILES COc1cc(F)ccc1-c1ncnc(Nc2cccc(C[S@@](C)(=N)=O)c2)n1

InChI Key InChIKey=ACWKGTGIJRCOOM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50516532   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50516532(CHEMBL4560679)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant GST-tagged human CDK2/cyclin-E expressed in sf9 cels using biotin-Ttds-YISPLKSPYKISEG as substrate preincubated for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50516532(CHEMBL4560679)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant full length His-tagged human CDK9/cyclin-T1 expressed in insect cells using biotin-Ttds-YISPLKSPYKISEG as substrate preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50516532(CHEMBL4560679)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50516532(CHEMBL4560679)
Affinity DataIC50: 6nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50516532(CHEMBL4560679)
Affinity DataIC50: 8.80nMAssay Description:Inhibition of CDK9/cyclin T1 (unknown origin) using as PDKtide substrate incubated for 1 hr in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50516532(CHEMBL4560679)
Affinity DataIC50: 975nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) incubated for 1 hr in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed