BDBM50516484 CHEMBL4513405

SMILES COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1)-c1ccc2OCC(=O)N(c3ccc(C)cc3)c2c1

InChI Key InChIKey=VSSMIYHJVDZVQW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50516484   

LigandPNGBDBM50516484(CHEMBL4513405)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged PI3Kdelta (1 to 1044 residues)/PIK3R1 (1 to 724 residues) expressed in baculovirus ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
LigandPNGBDBM50516484(CHEMBL4513405)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged PI3Kalpha (1 to 1068 residues)/PIK3R1 (1 to 724 residues) expressed in baculovirus ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50516484(CHEMBL4513405)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged mTOR (1362 to end residues) using Ulight-4E-BP1 as substrate incubated for 30 mins by fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed