BDBM50516280 CHEMBL4467809

SMILES Nc1n[nH]c2cc(ccc12)-c1ccc(cc1)C(=O)NCCNC(=O)c1ccc(Cl)c(c1)C(F)(F)F

InChI Key InChIKey=FZXLZZAXHCHSEG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50516280   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50516280(CHEMBL4467809)
Affinity DataIC50: 1.51E+4nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged SRC expressed in Escherichia coli using KVEKIGEGTYGVVYK-amide as substrate measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50516280(CHEMBL4467809)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant N-terminal GST tagged HCK (230 to 497 residues) expressed in baculovirus infected Sf9 cells using poly (Glu,Tyr) 4:1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50516280(CHEMBL4467809)
Affinity DataIC50: 3.45E+4nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged p38alpha expressed in baculovirus infected Sf9 cells using p38 peptide as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50516280(CHEMBL4467809)
Affinity DataIC50: 43nMAssay Description:Inhibition of wild type BCR/ABL (unknown origin) measured after 60 mins in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50516280(CHEMBL4467809)
Affinity DataIC50: 170nMAssay Description:Inhibition of BCR/ABL T315I mutant (unknown origin) measured after 60 mins in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed