BDBM50516024 CHEMBL4540705

SMILES C[C@@]12COCCN1c1nc(ncc1N(CC1CC1)C2=O)-c1ccc(NC(=O)NC2CC2)cc1

InChI Key InChIKey=QSUSKMROELIXNC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50516024   

TargetSerine/threonine-protein kinase mTOR(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50516024(CHEMBL4540705)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human mTOR measured after 30 mins in presence of ATP by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
LigandPNGBDBM50516024(CHEMBL4540705)
Affinity DataIC50: 794nMAssay Description:Inhibition of PI3K alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50516024(CHEMBL4540705)
Affinity DataIC50: 38nMAssay Description:Inhibition of mTORC2 in human PC-3 cells assessed as AKT phosphorylation at S473 residue in incubated for 1 hr by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed