BDBM50515969 CHEMBL4516759

SMILES CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2csc(CNC(=O)C(F)(F)[C@H](NC1=O)\C=C\CCS)n2

InChI Key InChIKey=KWYJMURUTYYRHS-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50515969   

TargetHistone deacetylase 8(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50515969(CHEMBL4516759)
Affinity DataIC50: 166nMAssay Description:Inhibition of full length C-terminal His-tagged human HDAC8 expressed in baculovirus infected Sf9 cells using Ac-peptide-AMC as substrate preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50515969(CHEMBL4516759)
Affinity DataIC50: 9.30nMAssay Description:Inhibition of recombinant full length human HDAC2 expressed in baculovirus infected Sf9 cells using Ac-peptide-AMC as substrate preincubated for 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50515969(CHEMBL4516759)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of recombinant full length C-terminal FLAG/His-tagged human HDAC1 expressed in baculovirus infected Sf9 cells using Ac-peptide-AMC as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
LigandPNGBDBM50515969(CHEMBL4516759)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of human recombinant full length C-terminal His-tagged HDAC3 (1 to 428 residues)/N-terminal GST-tagged NCOR2 (395 to 489 residues) express...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50515969(CHEMBL4516759)
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of recombinant human HDAC6 using Ac-peptide-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 60...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed