BDBM50515531 CHEMBL4452177

SMILES Cc1ccc(cc1)C(=O)\C=C\C(=O)N(C(C(=O)NCc1ccccc1)c1ncc(C)cn1)C1CC1

InChI Key InChIKey=ZMLWDTSYBVZHLZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50515531   

TargetThioredoxin reductase 1, cytoplasmic(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50515531(CHEMBL4452177)
Affinity DataIC50: 3.18E+4nMAssay Description:Inhibition of TrxR in human SH-SY5Y cells using DTNB as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetThioredoxin reductase 1, cytoplasmic(Rat)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50515531(CHEMBL4452177)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of rat TrxR1 using DTNB as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetThioredoxin reductase 1, cytoplasmic(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50515531(CHEMBL4452177)
Affinity DataIC50: 6.61E+3nMAssay Description:Inhibition of TrxR1 (unknown origin) using DTNB as substrate preincubated for 30 mins in presence of insulin followed by substrate addition by colori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed