BDBM50515528 CHEMBL4459518

SMILES CN(CCOC(=O)\C=C\C(=O)c1ccc(F)cc1)C(C(=O)NC(C)(C)C)c1ccc(F)cc1

InChI Key InChIKey=RJGWWNVHLMPYEN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50515528   

TargetThioredoxin reductase 1, cytoplasmic(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50515528(CHEMBL4459518)
Affinity DataIC50: 7.26E+3nMAssay Description:Inhibition of TrxR in human SH-SY5Y cells using DTNB as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetThioredoxin reductase 1, cytoplasmic(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50515528(CHEMBL4459518)
Affinity DataIC50: 960nMAssay Description:Inhibition of TrxR1 (unknown origin) using DTNB as substrate preincubated for 30 mins in presence of insulin followed by substrate addition by colori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetThioredoxin reductase 1, cytoplasmic(Rat)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50515528(CHEMBL4459518)
Affinity DataIC50: 600nMAssay Description:Inhibition of rat TrxR1 using DTNB as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetThioredoxin reductase 1, cytoplasmic(Rat)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50515528(CHEMBL4459518)
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant rat TrxR1 using DTNB as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins by color...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed