BDBM50515498 CHEMBL4463898

SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(CC1)C(=O)Cn1cncc1[N+]([O-])=O

InChI Key InChIKey=OQOUVSHMBYJEIH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50515498   

TargetEpidermal growth factor receptor(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50515498(CHEMBL4463898)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system using FAM-22 pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50515498(CHEMBL4463898)
Affinity DataIC50: 27nMAssay Description:Inhibition of N-terminal GST-tagged human VEGFR2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system using FAM-22 pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50515498(CHEMBL4463898)
Affinity DataIC50: 1.64E+3nMAssay Description:Inhibition of EGFR in human A-431 cells assessed as antiproliferative activity incubated for 48 hrs by MTS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed