BDBM50514943 CHEMBL4463353

SMILES CC1(C)Cc2cc(NC(=O)c3cnn4c(O)ccnc34)c(cc2O1)N1CCOCC1

InChI Key InChIKey=OJCRUMWRMOCSGX-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50514943   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50514943(CHEMBL4463353)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of IRAK4 in human THP1-Xblue-MD2-CD14 cells assessed as reduction in LPS-induced NFkappaB transcription by measuring alkaline phosphatase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50514943(CHEMBL4463353)
Affinity DataKi: >8.40E+3nMAssay Description:Inhibition of human recombinant full length His6-tagged IRAK4 expressed in baculovirus expression system using H-KKARFSRFAGSSPSQSSMVAR as substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed