BDBM50514936 CHEMBL4452936::US10988478, Example 245

SMILES CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(cc2O1)N1CCC(CC1)C(O)C(F)(F)F

InChI Key InChIKey=JVOOIOZXYFXQJZ-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50514936   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50514936(CHEMBL4452936 | US10988478, Example 245)
Affinity DataIC50: 56nMAssay Description:Inhibition of IRAK4 in human THP1-Xblue-MD2-CD14 cells assessed as reduction in LPS-induced NFkappaB transcription by measuring alkaline phosphatase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50514936(CHEMBL4452936 | US10988478, Example 245)
Affinity DataKi:  10nMAssay Description:Inhibition of human recombinant full length His6-tagged IRAK4 expressed in baculovirus expression system using H-KKARFSRFAGSSPSQSSMVAR as substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50514936(CHEMBL4452936 | US10988478, Example 245)
Affinity DataKi:  10nMAssay Description:Kinase activities were assayed using the Transcreener-Fluorecescence polarization platform (BelBrook Labs, Madison, Wis., USA) that measures amounts ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
Go to US Patent