BDBM50514933 CHEMBL4462969::US10988478, Example 91

SMILES CC1(C)Cc2cc(NC(=O)c3cnn4cc(cnc34)C(F)F)c(cc2O1)N1CCOCC1

InChI Key InChIKey=RWLDBBQGCNIFOB-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50514933   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50514933(CHEMBL4462969 | US10988478, Example 91)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of IRAK4 in human THP1-Xblue-MD2-CD14 cells assessed as reduction in LPS-induced NFkappaB transcription by measuring alkaline phosphatase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50514933(CHEMBL4462969 | US10988478, Example 91)
Affinity DataKi:  31nMAssay Description:Inhibition of human recombinant full length His6-tagged IRAK4 expressed in baculovirus expression system using H-KKARFSRFAGSSPSQSSMVAR as substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50514933(CHEMBL4462969 | US10988478, Example 91)
Affinity DataKi:  39nMAssay Description:Kinase activities were assayed using the Transcreener-Fluorecescence polarization platform (BelBrook Labs, Madison, Wis., USA) that measures amounts ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
Go to US Patent