BDBM50514926 CHEMBL4554579

SMILES OCC1CCN(CC1)c1cc2nc[nH]c2cc1NC(=O)c1cnn2cccnc12

InChI Key InChIKey=ZJRJENCIESBXJL-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50514926   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50514926(CHEMBL4554579)
Affinity DataIC50: 330nMAssay Description:Inhibition of IRAK4 in human THP1-Xblue-MD2-CD14 cells assessed as reduction in LPS-induced NFkappaB transcription by measuring alkaline phosphatase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50514926(CHEMBL4554579)
Affinity DataKi:  6.70nMAssay Description:Inhibition of human recombinant full length His6-tagged IRAK4 expressed in baculovirus expression system using H-KKARFSRFAGSSPSQSSMVAR as substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50514926(CHEMBL4554579)
Affinity DataKi: >5.70E+3nMAssay Description:Inhibition of human recombinant full length N-terminal His6-tagged IRAK1 (Argl94 to Ser712 residues) expressed in insect cells using H-KKARFSRFAGSSPS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed