BDBM50514534 CHEMBL4515441::US12365664, Compound 18

SMILES CN1CCN(CC1)c1ccc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)c(Nc3ccccc3NC(=O)C=C)n2)cc1

InChI Key InChIKey=HLRQYOGLZWIOPA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50514534   

TargetTyrosine-protein kinase HCK(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50514534(CHEMBL4515441 | US12365664, Compound 18)
Affinity DataIC50: 3nMAssay Description:Inhibition of HCK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50514534(CHEMBL4515441 | US12365664, Compound 18)
Affinity DataIC50: 8.34E+3nMAssay Description:Inhibition of recombinant human His-tagged FGFR1 (308 to 731 residues) expressed in baculovirus expression system using tyrosine-4 peptide as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50514534(CHEMBL4515441 | US12365664, Compound 18)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human His-tagged full length SRC expressed in baculovirus expression system using tyrosine-2 peptide as substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50514534(CHEMBL4515441 | US12365664, Compound 18)
Affinity DataIC50: 3nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50514534(CHEMBL4515441 | US12365664, Compound 18)
Affinity DataIC50: 5.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Yes(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50514534(CHEMBL4515441 | US12365664, Compound 18)
In Depth
Date in BDB:
11/3/2025
Entry Details
Go to US Patent