BDBM50514474 CHEMBL4462152

SMILES CCCc1cc(ccc1OCc1ccc(cc1)C(F)(F)F)-c1noc(n1)[C@@H]1CCCN1C(N)=N

InChI Key InChIKey=MCGAWAWGTLGVTA-UHFFFAOYSA-N

Data  2 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50514474   

TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandPNGBDBM50514474(CHEMBL4462152)
Affinity DataEC50:  37nMAssay Description:Inhibition of human SphK2 expressed in Saccharomyces cerevisiae KYA1 assessed as yeast growth measured after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Virginia Tech

Curated by ChEMBL
LigandPNGBDBM50514474(CHEMBL4462152)
Affinity DataEC50: >800nMAssay Description:Inhibition of human SphK1 expressed in Saccharomyces cerevisiae KYA1 assessed as yeast growth measured after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Virginia Tech

Curated by ChEMBL
LigandPNGBDBM50514474(CHEMBL4462152)
Affinity DataKi:  201nMAssay Description:Inhibition of recombinant human SphK2 expressed in baculovirus infected Sf9 cells assessed as decrease in [33P]S1P production using varying level of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Virginia Tech

Curated by ChEMBL
LigandPNGBDBM50514474(CHEMBL4462152)
Affinity DataKi:  9.60E+3nMAssay Description:Inhibition of recombinant human SphK1 expressed in baculovirus infected Sf9 cells assessed as decrease in [33P]SIP production using varying level of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed