BDBM50514312 CHEMBL4446421

SMILES COc1ccccc1S(=O)(=O)Nc1ccc2N(C)C(=O)c3cc(nc1c23)-n1cnc(C)c1

InChI Key InChIKey=FSMTUHGXWGJNKK-UHFFFAOYSA-N

Data  8 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50514312   

TargetBromodomain-containing protein 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50514312(CHEMBL4446421)
Affinity DataIC50: 1.21E+4nMAssay Description:Displacement of tetra-acetylated histone H4 peptide (1-21) from recombinant human N-terminal His-tagged BRD4 BD2 (349 to 460 residues) expressed in E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetBromodomain testis-specific protein(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50514312(CHEMBL4446421)
Affinity DataIC50: 357nMAssay Description:Displacement of tetra-acetylated histone H4 peptide (1-21) from BRDT BD1 (unknown origin) incubated for 30 mins followed by further incubation with t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50514312(CHEMBL4446421)
Affinity DataIC50: 88nMAssay Description:Displacement of tetra-acetylated histone H4 peptide (1-21) from recombinant human N-terminal His-tagged BRD4 BD1 (44 to 170 residues) expressed in Es...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50514312(CHEMBL4446421)
Affinity DataIC50: 8.95E+3nMAssay Description:Displacement of tetra-acetylated histone H4 peptide (1-21) from BRD2 BD1 (unknown origin) incubated for 30 mins followed by further incubation with t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50514312(CHEMBL4446421)
Affinity DataIC50: 2.15E+4nMAssay Description:Displacement of tetra-acetylated histone H4 peptide (1-21) from BRD2 BD2 (unknown origin) incubated for 30 mins followed by further incubation with t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50514312(CHEMBL4446421)
Affinity DataIC50: 4.98E+4nMAssay Description:Displacement of tetra-acetylated histone H4 peptide (1-21) from BRD3 BD2 (unknown origin) incubated for 30 mins followed by further incubation with t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50514312(CHEMBL4446421)
Affinity DataKd:  1.05E+5nMAssay Description:Binding affinity to immobilized DNA-tagged human BRD4 BD1 by BROMOscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPeregrin(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50514312(CHEMBL4446421)
Affinity DataIC50: 568nMAssay Description:Displacement of tetra-acetylated histone H4 peptide (1-21) from BRPF1b (unknown origin) incubated for 30 mins followed by further incubation with tet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50514312(CHEMBL4446421)
Affinity DataIC50: 246nMAssay Description:Displacement of tetra-acetylated histone H4 peptide (1-21) from BRD3 BD1 (unknown origin) incubated for 30 mins followed by further incubation with t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50514312(CHEMBL4446421)
Affinity DataKd: >2.50E+4nMAssay Description:Binding affinity to immobilized DNA-tagged human BRD4 BD2 by BROMOscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed