BDBM50514245 CHEMBL4461774

SMILES Fc1ccccc1CCN1CCC2(CC1)CN(C(=O)C1(CC1)O2)c1cccnc1C(F)(F)F

InChI Key InChIKey=QNSPFRSAEHVDGL-UHFFFAOYSA-N

Data  9 KI  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50514245   

TargetMu-type opioid receptor(Human)
Esteve Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50514245(CHEMBL4461774)
Affinity DataEC50:  195nMAssay Description:Agonist activity at human MOR expressed in CHOK1 cells assessed as stimulation of cAMP accumulation incubated for 45 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Esteve Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50514245(CHEMBL4461774)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in channel current at -80 mV holding potential by whole cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Esteve Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50514245(CHEMBL4461774)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by whole cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Esteve Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50514245(CHEMBL4461774)
Affinity DataEC50:  195nMAssay Description:Agonist activity at human MOR expressed in CHOK1 cells assessed as stimulation of cAMP accumulation incubated for 45 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Esteve Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50514245(CHEMBL4461774)
Affinity DataKi:  58nMAssay Description:Displacement of [3H]-(+)-pentazocine from human sigma-1 receptor expressed in HEK293 membranes incubated for 120 mins by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Esteve Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50514245(CHEMBL4461774)
Affinity DataKi:  58nMAssay Description:Displacement of 3H](+)-pentazocine from human sigma1 receptor expressed in HEK293 cell membranes incubated for 120 mins by liquid scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Esteve Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50514245(CHEMBL4461774)
Affinity DataKi:  58nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in CHO-K1 cell membranes incubated for 90 mins measured by MicroBeta scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Esteve Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50514245(CHEMBL4461774)
Affinity DataKi:  58nMAssay Description:Antagonist activity at sigma1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
Esteve Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50514245(CHEMBL4461774)
Affinity DataKi:  175nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in CHOK1 cell membranes incubated for 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Esteve Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50514245(CHEMBL4461774)
Affinity DataKi:  175nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in CHOK1 cell membranes incubated for 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Jiangsu Ocean University

Curated by ChEMBL
LigandPNGBDBM50514245(CHEMBL4461774)
Affinity DataKi:  175nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Esteve Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50514245(CHEMBL4461774)
Affinity DataKi:  470nMAssay Description:Displacement of [3H]-prazosin from human alpha1A adrenoreceptor expressed in enriched membranes incubated for 90 mins by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Esteve Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50514245(CHEMBL4461774)
Affinity DataKi:  754nMAssay Description:Inhibition of 5HT2B receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed