BDBM50514068 CHEMBL4435327

SMILES [O-]S(=O)(=O)Oc1ccc(cc1)-c1nc2ccccc2c(=O)n1CCCCCCCCn1cc(COc2cc(OS([O-])(=O)=O)cc3oc(-c4ccc(OS([O-])(=O)=O)c(OS([O-])(=O)=O)c4)c(OS([O-])(=O)=O)c(=O)c23)nn1

InChI Key InChIKey=MVLBWJODIRTTSK-UHFFFAOYSA-I

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50514068   

TargetPlasminogen(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50514068(CHEMBL4435327)
Affinity DataIC50: 4.50E+4nMAssay Description:Direct inhibition of human Lys-plasmin preincubated for 5 mins followed by Spectrozyme PL addition by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProthrombin(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50514068(CHEMBL4435327)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of thrombin (unknown origin) assessed as reduction in hydrolysis activity preincubated for 10 mins followed by spectrozyme THMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50514068(CHEMBL4435327)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of human factor 10a (unknown origin) assessed as reduction in hydrolysis activity preincubated for 10 mins followed by spectrozyme FXaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50514068(CHEMBL4435327)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human FXIa using S-2366 as chromogenic substrate preincubated with enzyme for 10 mins followed by substrate addition by spectrophotomet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed