BDBM50514045 CHEMBL4446782::US10858356, Example 67

SMILES C[C@H]1C[C@]1(c1noc(=O)[nH]1)n1c(cc2cc(ccc12)[C@H]1CCOC(C)(C)C1)C(=O)N1CCc2nn(c(c2[C@@H]1C)-n1ccn(-c2ccc3n(C)ncc3c2F)c1=O)-c1cc(C)c(F)c(C)c1

InChI Key InChIKey=USUWIEBBBWHKNI-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50514045   

TargetGlucagon-like peptide 1 receptor(Human)
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50514045(CHEMBL4446782 | US10858356, Example 67)
Affinity DataEC50:  600nMAssay Description:Positive allosteric modulator activity at human GLP-1R expressed in PSC-HEK293 cells in presence of EC20 level of GLP1(9-36)NH2 incubated for 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Mouse)
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50514045(CHEMBL4446782 | US10858356, Example 67)
Affinity DataEC50:  300nMAssay Description:Positive allosteric modulator activity at mouse GLP-1R expressed in PSC-HEK293 cells in presence of EC20 level of GLP1(9-36)NH2 incubated for 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50514045(CHEMBL4446782 | US10858356, Example 67)
Affinity DataEC50:  1.20nMAssay Description:hGLP1R-HEK293 was seeded in 96 well plates at 2.0×104 cells per well and cultured over night. The medium for culturing the cells was changed to 50 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
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