BDBM50513220 CHEMBL4435044

SMILES [H][C@]12Cc3c([nH]c4ccccc34)[C@H](N1C(=O)CN(CCC1CCN(Cc3ccccc3)CC1)C2=O)c1ccc2OCOc2c1

InChI Key InChIKey=KVANOXIAOYTXBY-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50513220   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50: 1.53E+3nMAssay Description:Inhibition of PDE5A1 (unknown origin) by immobilized metal ion affinity-based fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50: 3.88E+3nMAssay Description:Inhibition of BuChE from rat serum by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDE2A1 (unknown origin) by immobilized metal ion affinity-based fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDE6C (unknown origin) by immobilized metal ion affinity-based fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDE7A (unknown origin) by immobilized metal ion affinity-based fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50: 32nMAssay Description:Inhibition of AChE from rat cortex by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDE9A2 (unknown origin) by immobilized metal ion affinity-based fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDE3A (unknown origin) by immobilized metal ion affinity-based fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50: 36nMAssay Description:Inhibition of PDE5A1 (unknown origin) using FAM-cGMP as substrate incubated for 60 mins by IMAP-fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetAcetylcholinesterase(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50: 153nMAssay Description:Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate incubated for 20 mins by DTNB-reagent based Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed